Ketoconazole was discovered in 1976 and released in the early 1980s, and was one of the first available oral treatment for fungal infections (griseofulvin was available before ketoconazole).

Ketoconazole is also sometimes used to treat prostate cancer (cancer that begins in a male reproductive organ), high blood levels of calcium in patients with certain conditions, Cushing's syndrome (high blood levels of a natural substance called cortisol), and excessive hair growth in women.

Ketoconazole is in a class of antifungals called imidazoles. It works by slowing the growth of fungi that cause infection.

It is used to treat yeast infections of the mouth, throat, and esophagus, as well as fungal infections throughout the whole body and serious fungal infections of the skin and nails.

The over-the-counter shampoo version of ketoconazole can also be used as a body wash for the treatment of tinea versicolor.

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